Klebsiella pneumoniae is one of the most frequently isolated bacteria from the Intensive Care Unit of the hospitals, and recently carbapenemase-producing bacteria constitute the largest proportion in the antibacterial resistant bacteria. The increase of the antibacterial resistant bacteria like carbapenem-resistant Klebsiella pneumoniae really increases the morbidity and mortality.
The appearance of carbapenem-resistant Klebsiella pneumoniae is well known. However this began to appear since the late of 1990, but there were a few researches about the propensity and frequency of the antibacterial resistance in vitro. Furthermore there was few antibiotic resistance test related to the source of samples among carbapenem -resistant Klebsiella pneumoniae.
We analyzed the antibacterial resistance of Klebsiella pneumoniae in the in-patients, the type of resistance according to the source of sample and the cross-resistance between carbapenem-resistant Klebsiella pneumoniae.
We tested the antibiotic sensitivity in the in-patients from several hospitals from 2010 to 2012 and classified according to the specimens.(blood, urine, wound, sputum)
The resistance on all factors except for Tetracycline increased siginificantly and statistically. The highest increase of antibacterial resistance was observed in aztreonam(7.7~22.2%), ceftazidime(5.5~17.2%) and ciprofloxacin(5.5~16.8%).
Especially the bacteria isolated from the respiratory tract was higher in the resistance to all antibiotics but tetracycline than one isolated from urine.
The isolation rate of carbapenem-resistant Klebsiella pneumoniae was higher in the Intensive Care Unit than in the general ward.
The resistance rate of carbapenem-resistant Klebsiella pneumoniae increased from 1% to 8%.
It is very important to intensify the studies to prevent to the multi-drug resistance, the problem related to the use of antibiotics in the practice of medical care.
