The researchers in chemistry faculty of
S-malic acid and S-chlorosuccinic acid, chiral succinic acid derivatives are being widely used as raw materials for drug synthesis. S-malic acid and S-chlorosuccinic acid are essential raw materials for the synthesis of L-carnitine, paclitaxel(Taxol) and other physiological activators. And they have been proved to be very useful for food additives and pH controllers of amino acid medicines and resolution substances of chiral molecules and so on.
Therefore, the synthesis of S-malic acid and S-chlorosuccinic acid and their applications are being widely studied.
Many previous researchers had first synthesized their racemic mixtures by addition reaction of H2O or hydrogen chloride to fumaric acid or malleic acid and then they had turned to their diastereoisomers using the pure chiral substances and then they had resoluted to obtain S-malic acid or S-chlorosuccinic acid.
In chemistry faculty of
We measured their melting points, optical rotations, IR spectrums for the identifi-cation of their structures and their purities were determined by using Ultrahigh-speed liquid chromatography(UPLC), respectively.
In future, we are going to study synthetic methods of physiological regulation substances like L-carnitine from S-maleic acid and S-chlorosuccinic acid.
