Endometriosis(EMS) is a common gynecological condition in which the endometrium-like tissue is found outside the uterine cavity. It is highly important to understand its etiology, because it has been linked to Pelvic pain, multiple operations, and infertility and difficult to cure of. Nowadays, the exact mechanism for the development of endometriosis is unclear. The most widely accepted theory is implantation of viable endometrium on peritoneal surfaces after retrograde menstruation. However, it is well established that menstrual debris is present in the peritoneal cavity of 90% of menstruating women, but only 10-15% women are capable of establishing ectopic endometrial implants. There are several possible explanations for such susceptibility, including differencesin genetic predisposition, increased exposure to menstrual debris, abnormal eutopic endometrium, altered peritoneal environment, reduced immune surveillanee, and increased angiogenic capacity. Familial and epidemiologic studies support that this disease is a genetic disorder of polygenic/multifactorial inheritance.
Lecturers of Koryo obstetric and gynecology department in Pyongyang Medical College of
The aim is to find the action of PR in the development of endometriosis. On second thoughts, because inactivation of 17β-estradiol to estrone is catalyzed by 17β phydroxysteroid dehydrogenase type 2(17βHSD2) in the human endometrium, progesterone stimulates to produce 17βHSD2 by the action of PR. Study on 17βHSD2 Will be beneficial to understand the mechanism that endometriosis is an estrogen-dependent disease.
Our research group is studing for has come the purpose.
