Morbidity and mortality of noninfectious diseases (NIDs) such as myocardial Infarction, stroke, diabetes mellitus, hypertension, hyperlipaemia and obesity increased in 21century.
The Medical Genetics Department, Basic Medical Faculty, Pyongyang Medical College of
Metabolic syndrome is recognized as basic diseases of noninfectious disease because it consists of obesity, hypertension, dysglycemia, abnormal blood serum lipid etc.
Diagnostic Criteria for the Metabolic Syndrome differ in the World Health Organization (WHO), the European Group for the Study on Insulin Resistance (EGIR), the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III), and International Diabetes Federation (IDF) and no common diagnosticcriteria have been established yet.
The prevalence rate of MetS in the world is 10~50 percent. It is average 25 percent in the asymptomatic individuals and the prevalence rate and the risk of attack agentsvary depending on the country, region, race, nationality and socioeconomic situateion.
Also the genetic influence on metabolic syndrome varies depending on the nations and races.
In our country the study on genetic characteristics of diabetes, hypertension and obesityis in progress but that on metabolic syndrome is only on the therapeutic stage.
Therefore, to create the basic means that can prevent the obese individuals and the genetically predisposed individuals from metabolic syndrome, the study is aimed at determining the genetic characteristics of metabolic syndrome and its components in the first-degree relatives of the central obesity family.
The subjects who had been tested serum lipids and blood glucose in the hospitals of the Pyongyang City took anthropometry and were divided into two groups; one withobese and the other without it. The range of the age and sex of the subjects in each group was ±2years of age and their parents, sibs, offspring took blood biochemical test and waist circumference, blood pressure.
The study group consisted of 30 individuals with central obesity(average age 56.1±11.7) and 153 their first-degree relatives (average age 43.5±15.1) and the central group consisted of 31 individuals without central obesity (average age 57.3±6.7)and 131 their first-degree relatives (average age 45.3±16.1).
Waist circumference was measured at midway between iliac crest and lower rib margin at the end of deep expiration using a plastic flexible tape to the nearest 0.1 cm.
The unit is cm. Central obesity was defined as having waist circumference ≧90cm for men and ≧ 80cm for women.
Seated blood pressure was taken three times of each systolic and diastolic blood pressure after at least a 10-minute rest with mercury sphygmomanometer.
Blood glucose, triglycerides(TG) and high density lipoprotein cholesterol(HDL-C) were measured with university biochemistry analyser(MIND RAY BS 490).
The diagnosis of MetS used the Adult Treatment Panels of the Third Report of the National Cholesterol Education Program (NCEP/ATPIII) modified for Asians.
MetS is definited as having at least 3 components of 5, that is, waist circumference; ≥80cm in females and ≥90 cm in males, elevated triglycerides; ≥150 mg/dl (1.7 mmol/l),reduced HDL–cholesterol level; <50 mg/dl(1.3 mmol/l) in females and <40mg/dl (1.0 mmol/l) in males, elevated systolic blood pressure ≥130 mmHg and/or diastolic ≥85mm Hg, elevated fasting blood glucose ≥100 mg/dl (5.6 mmol/l).
All statistical analyses were performed using SPSS12.0
Inheritance mode of metabolic syndrome and its components were determined throughthe estimation of relative frequency predict value and observation value frequency in the sibs.
Heritability of metabolic syndrome was counted with maximum likelihood method.
The conclusion acquired from the result is as follows.
First, MetS and its components in the central obesity family show autosomal recessive or multifactorial inheritance mode and the familial aggregation rate was high significantly compared to non-obesity family.
Second, the heritability of metabolic syndrome in the central obesity family is 60.1 percent and the heritability of combination of blood glucose, lipids, obesity is 47.7 percent, the heritability of combination of blood glucose, lipids, hypertension is 36.8 percent, and the heritability of combination of blood glucose, obesity, hypertension is 24.4 percent.
The research will contribute to the determining the risk of hereditary factors to MetS and to the establishment of the prevention method. We hope you will find them useful and want co-study.
